Chapman Teaching

CON 668: Molecular Biophysics & Experimental Bioinformatics

Introduction to Macromolecular X-ray crystallography (2 lectures):

Fatty Acid Synthase (2 meetings; Fall 2008):

Structure & Activity of tuberculosis Toxin/Anti-toxin systems (2 meetings; Fall 2009):

Background (PowerPoint)

Macromolecular Crystallography - October / November 2009

Week	Topics	Practicals
1	Introduction (PowerPoint) (PDF handout); Crystallization (PowerPoint) (PDF handout)	Lysozyme crystallization lab (PDF)
2	Diffraction theory & Data collection (PowerPoint) (PDF handout)
3	The Phase Problem (PowerPoint) (PDF handout)
4	Modeling, Refinement, Accuracy & Validation (PowerPoint) (PDF handout)	Building with computer graphics (Modeling_tutorial.htm)


by Michael S. Chapman